Endocrine Abstracts

Background & Aims: ATP binding cassette subfamily G1 (ABCG1) is involved in mediating cholesterol efflux and modulating cellular lipid homeostasis. It is influenced by endogenous glucose and our aim was to examine the relationship between ABCG1 expression and lipid profiles within the increased glucose levels of subjects with Type 2 diabetes (ODM).Methods: RNA was extracted from visceral fat collected from subjects undergoing abdominal surgery (baria...

Little has been published on the long-term management of thyrotoxicosis with antithyroid drugs (ATDs). We analysed 376 thyrotoxic subjects on the Morriston database since 2002. 170 had Graves’ disease, 181 toxic multinodular goitre (TMNG); in 25 the diagnosis was not recorded. When euthyroid subjects were requested to have annual thyroid function testing 42 (11%) had died. 111(30%) did not have TFT’s done in last two years. 135 graves’s cases were given ATDs whi...

Background: Literature suggests that whole glucose excursion, rather than plasma glucose concentration at a point, provides more information about glucose tolerance. The glucose area under the curve (AUC) is an index of whole glucose excursion after glucose load. We sought to investigate changes in insulin and glucose homeostasis, including the glucose AUC, 5 years after bariatric surgery.Method: A non-randomised prospective study of 18 participants with...

Background: Bariatric surgery aims to decrease cardiovascular risk factors. The Swedish Obese Subjects study reported that bariatric surgery was associated with reduction in long-term cardiovascular (CV) event. However, uncertainty remains regarding the effect of bariatric surgery on long-term CV risk. One way to predict long-term CV risk after bariatric surgery is to use cardiovascular risk assessment models.Aim: The aim of this study is to investigate ...

Introduction: Pituitary Apoplexy is a rare endocrine emergency which can occur due to infarction or haemorrhage of pituitary gland. Pituitary apoplexy can occur as an initial presentation in patients who are not known to have Pituitary adenomas. Clinical Symptoms vary, however, one should have a high index of suspicion if symptoms such as acute headache, visual loss or ocular palsy occur.Precipitating factors: Hypertension, Preganancy, Head trauma, Dynam...